Fzd2 Gene Summary [Rat]
Enables Wnt receptor activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; Wnt signaling pathway; and cellular response to vitamin D. Located in plasma membrane. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in omodysplasia 2. Orthologous to human FZD2 (frizzled class receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fzd2 |
| Official Name | frizzled class receptor 2 [Source:RGD Symbol;Acc:71012] |
| Ensembl ID | ENSRNOG00000021962 |
| Bio databases IDs | |
| Aliases | frizzled class receptor 2 |
| Synonyms | D15MGI12, FRIZZLED 2, frizzled class receptor 2, Frizzled homolog 2, Fz-10, Fz2, Fzd10, fzE2, hFz2, Mfz10, Mfz10a, OMOD2, Rfz2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fzd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- intracellular loop
- Frizzled/Smoothened family membrane region
- Wnt receptor
- Fz domain
- protein binding
- identical protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
- PDZ-domain binding
- cytoplasmic domain
- intracellular domain
- PDZ binding motif
- cysteine rich domain
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Fzd2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Basal Cell Carcinoma Signaling
- Cellular Effects of Sildenafil (Viagra)
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- CREB Signaling in Neurons
- Factors Promoting Cardiogenesis in Vertebrates
- G-Protein Coupled Receptor Signaling
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Mouse Embryonic Stem Cell Pluripotency
- Osteoarthritis Pathway
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- Wnt/Ca+ pathway
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- diabetic nephropathy
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- Huntington disease
- omodysplasia type 2
role in cell
- expression in
- accumulation in
- phosphorylation in
- invasion by
- apoptosis
- survival
- activation in
- aggregation
- differentiation
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endocytic vesicle membrane
- Cytoplasm
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fzd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- hard palate development
- planar cell polarity pathway involved in neural tube closure
- G-protein coupled receptor signaling pathway
- cochlea morphogenesis
- neuron differentiation
- muscular septum morphogenesis
- outflow tract morphogenesis
- cell-cell signaling
- endothelial cell differentiation
- inner ear receptor cell development
- positive regulation of sequence-specific DNA binding transcription factor activity
- membranous septum morphogenesis
- positive regulation of transcription, DNA-dependent
- sensory perception of smell
- Wnt receptor signaling pathway
- canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway, planar cell polarity pathway
- non-canonical Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- clathrin-coated endocytic vesicle membrane
- focal adhesion
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- Wnt-activated receptor activity
- protein binding
- PDZ domain binding
- Wnt-protein binding