Pde2a Gene Summary [Rat]
Enables identical protein binding activity. Involved in several processes, including establishment of endothelial barrier; negative regulation of cAMP/PKA signal transduction; and response to hydrogen sulfide. Located in hippocampal mossy fiber; mitochondrion; and synaptic membrane. Biomarker of cardiomyopathy. Orthologous to human PDE2A (phosphodiesterase 2A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pde2a |
| Official Name | phosphodiesterase 2A [Source:RGD Symbol;Acc:620965] |
| Ensembl ID | ENSRNOG00000019560 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 2A |
| Synonyms | bc029810, Cgmp-stimulated phosphodiesterase, CGS-PDE, IDDPADS, PDE2, PDE2A1, Pde2a2, PED2A4, phosphodiesterase 2A, phosphodiesterase 2A, cGMP-stimulated |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pde2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'5'-cyclic nucleotide phosphodiesterase
- 3',5'-cyclic-GMP phosphodiesterase
- cGMP-stimulated cyclic-nucleotide phosphodiesterase
- cAMP-specific phosphodiesterase
- protein domain specific binding
- enzyme
- protein binding
- magnesium ion binding
- phosphate binding
- identical protein binding
- Domain present in phytochromes and cGMP-specific phosphodiesterases
- Metal dependent phosphohydrolases with conserved 'HD' motif
- zinc ion binding
- GAF domain
- 3',5'-cAMP binding
- protein homodimerization
- HDc
- 3',5'-cGMP binding
Pathways
Biological processes and signaling networks where the Pde2a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- impaired glucose tolerance
- diabetes mellitus
- prostate cancer
- glaucoma
- Parkinson disease
- habitual abortion
- insomnia
- pulmonary hypertensive arterial disease
- congestive heart failure
- non-insulin-dependent diabetes mellitus
role in cell
- activation in
- migration
- proliferation
- production in
- organization
- response by
- angiogenesis by
- shortening
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- presynaptic membrane
- synaptic membrane
- mitochondrial matrix
- mitochondrial outer membrane
- mitochondrial inner membrane
- synaptic vesicles
- mitoplasts
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pde2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- cGMP-mediated signaling
- regulation of cAMP-mediated signaling
- heart valve development
- ventricular septum development
- positive regulation of inflammatory response
- negative regulation of vascular permeability
- establishment of endothelial barrier
- negative regulation of cAMP-mediated signaling
- positive regulation of vascular permeability
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to transforming growth factor beta stimulus
- cellular response to mechanical stimulus
- cellular response to cGMP
- aorta development
- cGMP catabolic process
- positive regulation of gene expression
- cellular response to cAMP
- negative regulation of cGMP-mediated signaling
- regulation of mitochondrion organization
- cellular response to macrophage colony-stimulating factor stimulus
- cAMP-mediated signaling
- regulation of cGMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- Golgi apparatus
- endoplasmic reticulum
- synaptic membrane
- mitochondrial outer membrane
- mitochondrial inner membrane
- plasma membrane
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- mitochondrial matrix
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- zinc ion binding
- TPR domain binding
- protein homodimerization activity
- protein binding
- cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
- cAMP binding
- 3',5'-cyclic-GMP phosphodiesterase activity
- phosphate ion binding
- cGMP binding
- 3',5'-cyclic-AMP phosphodiesterase activity