Pik3r5 Gene Summary [Rat]
Enables 1-phosphatidylinositol-3-kinase regulator activity. Involved in phosphatidylinositol metabolic process. Part of phosphatidylinositol 3-kinase complex. Human ortholog(s) of this gene implicated in ataxia with oculomotor apraxia type 3 and colon cancer. Orthologous to human PIK3R5 (phosphoinositide-3-kinase regulatory subunit 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pik3r5 |
| Official Name | phosphoinositide-3-kinase, regulatory subunit 5 [Source:RGD Symbol;Acc:1563261] |
| Ensembl ID | ENSRNOG00000023428 |
| Bio databases IDs | |
| Aliases | phosphoinositide-3-kinase, regulatory subunit 5 |
| Synonyms | AV230647, F730038I15RIK, FOAP-2, p101, P101-PI3K, phosphoinositide-3-kinase regulatory subunit 5, phosphoinositide-3-kinase, regulatory subunit 5, RGD1563261 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pik3r5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Phosphoinositide 3-kinase gamma adapter protein p101 subunit
- phosphatidylinositol 3-kinase regulator
- phosphatidylinositol-4-phosphate 3-kinase
- binding protein
- phosphatidylinositol-4,5-bisphosphate 3-kinase
Pathways
Biological processes and signaling networks where the Pik3r5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Apelin Cardiomyocyte Signaling Pathway
- Clathrin-mediated Endocytosis Signaling
- CNTF Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- EGF Signaling
- ErbB Signaling
- ErbB4 Signaling
- Glucocorticoid Receptor Signaling
- Growth Hormone Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-9 Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- MSP-RON Signaling Pathway
- Neurotrophin/TRK Signaling
- NGF Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- p53 Signaling
- PDGF Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Th1 Pathway
- Th2 Pathway
- Thyroid Cancer Signaling
- UVA-Induced MAPK Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- hypothyroidism
- autoimmune thyroid disease
- Alzheimer disease
- renal clear cell adenocarcinoma
- renal clear cell cancer
- angioimmunoblastic T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
role in cell
- activation in
- phosphorylation in
- migration
- number
- recruitment
- growth
- transformation
- phagocytosis by
- colonization by
- phagocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pik3r5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- protein kinase B signaling cascade
- immune response
- G-protein coupled receptor signaling pathway
- phosphatidylinositol metabolic process
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex
- phosphatidylinositol 3-kinase complex
- nucleus
- 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex
- cytoplasm
- centriolar satellite
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein beta/gamma-subunit complex binding
- 1-phosphatidylinositol-3-kinase regulator activity