Pdgfd Gene Summary [Rat]
Predicted to enable platelet-derived growth factor receptor binding activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; positive regulation of cell migration; and positive regulation of cell population proliferation. Located in extracellular space. Used to study glomerulonephritis and mesangial proliferative glomerulonephritis. Biomarker of liver cirrhosis; mesangial proliferative glomerulonephritis; and myocardial infarction. Human ortholog(s) of this gene implicated in prostatic hypertrophy. Orthologous to human PDGFD (platelet derived growth factor D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdgfd |
| Official Name | platelet derived growth factor D [Source:RGD Symbol;Acc:621880] |
| Ensembl ID | ENSRNOG00000029148 |
| Bio databases IDs | |
| Aliases | platelet derived growth factor D |
| Synonyms | 1110003I09Rik, IEGF, MSTP036, platelet derived growth factor D, platelet-derived growth factor, D polypeptide, rSCDGF-B, SCDGF-B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pdgfd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CUB
- PDGF
- platelet-derived growth factor receptor binding
- growth factor
Pathways
Biological processes and signaling networks where the Pdgfd gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Atherosclerosis Signaling
- Clathrin-mediated Endocytosis Signaling
- Ephrin Receptor Signaling
- Glioblastoma Multiforme Signaling
- Glioma Signaling
- Human Embryonic Stem Cell Pluripotency
- Macropinocytosis Signaling
- PAK Signaling
- PDGF Signaling
- PPAR Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of PKR in Interferon Induction and Antiviral Response
- Sphingosine-1-phosphate Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- pulmonary hypertensive arterial disease
- endometriosis
- schizophrenia
- insulin-dependent diabetes mellitus
- acute myeloid leukemia
- osteoarthritis
- choroidal neovascularization
- gastric cancer
- severe preeclampsia
role in cell
- expression in
- apoptosis
- activation in
- chemotaxis
- proliferation
- phosphorylation in
- migration
- growth
- invasion
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pdgfd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- cellular response to platelet-derived growth factor stimulus
- positive regulation of cell proliferation
- platelet-derived growth factor receptor signaling pathway
- positive regulation of smooth muscle cell proliferation
- regulation of peptidyl-tyrosine phosphorylation
- cellular response to amino acid stimulus
- positive regulation of monocyte extravasation
- cellular response to transforming growth factor beta stimulus
- positive regulation of protein autophosphorylation
- positive regulation of smooth muscle cell chemotaxis
- positive regulation of cell division
- positive regulation of fibroblast proliferation
- positive regulation of ERK1 and ERK2 cascade
- cellular response to hydrogen peroxide
- positive regulation of glomerular mesangial cell proliferation
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- Golgi membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- platelet-derived growth factor receptor binding