Fndc1 Gene Summary [Rat]
Acts upstream of or within several processes, including cellular response to hypoxia; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of protein phosphorylation. Located in cell-cell junction; mitochondrial membrane; and plasma membrane. Orthologous to human FNDC1 (fibronectin type III domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fndc1 |
| Official Name | fibronectin type III domain containing 1 [Source:RGD Symbol;Acc:1310640] |
| Ensembl ID | ENSRNOG00000030210 |
| Bio databases IDs | |
| Aliases | fibronectin type III domain containing 1 |
| Synonyms | 1110027O12RIK, 1110051A18RIK, AGS8, bA243O10.1, dJ322A24.1, fibronectin type III domain containing 1, FNDC2, LOC100039091, MEL4B3, mKIAA1866 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fndc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FN3
- Purple acid Phosphatase, N-terminal domain
- Fibronectin type 3 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rectum cancer
- central nervous system cancer
- epithelial cancer
- colorectal carcinomagenesis
- rectal adenocarcinoma
- interstitial fibrosis
- adenoid cystic carcinoma
- lung adenocarcinoma
- lung adenocarcinoma formation
- HER2 negative hormone receptor negative breast cancer
role in cell
- phosphorylation in
- apoptosis
- differentiation
- response by
- cross-sectional area
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- intercellular junctions
- mitochondrial membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fndc1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular region