Bcl2a1 Gene Summary [Rat]
Enables BH domain binding activity. Involved in cerebral cortex development and response to cisplatin. Predicted to be located in cytoplasm. Predicted to be active in mitochondrial outer membrane. Orthologous to human BCL2A1 (BCL2 related protein A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bcl2a1 |
| Official Name | BCL2-related protein A1 [Source:RGD Symbol;Acc:620621] |
| Ensembl ID | ENSRNOG00000047606 |
| Bio databases IDs | |
| Aliases | BCL2-related protein A1 |
| Synonyms | ACC-1, ACC-2, BCL2A1A, BCL2A1D, BCL2L5, BCL2-related protein A1, Bfl1, BFL1/A1, GRS, HBPA1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bcl2a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bcl-2_like
- amphipathic tail-anchoring domain
- binding protein
- Bcl-2 homology 1 domain
- Bcl-2 homology 2 domain
- Bcl-2 homology 3 domain
- transmembrane domain
- protein domain specific binding
- protein binding
- glutamine-rich domain
Pathways
Biological processes and signaling networks where the Bcl2a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- mammary neoplasm
- eosinophilic esophagitis
- colorectal neoplasia
- glioma formation
- polycystic ovary syndrome
- primary sclerosing cholangitis
- glioma
- sepsis
- colon neoplasm
role in cell
- apoptosis
- cell death
- expression in
- growth
- proliferation
- differentiation
- cell viability
- quantity
- survival
- stabilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- outer leaflet
- mitochondrial membrane
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bcl2a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- negative regulation of apoptotic process
- mitochondrial fusion
- release of cytochrome c from mitochondria
- DNA damage response, signal transduction resulting in induction of apoptosis
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- BH domain binding
- channel activity
- protein binding