Wnt7a Gene Summary [Rat]
Enables frizzled binding activity. Involved in several processes, including canonical Wnt signaling pathway; positive regulation of JNK cascade; and response to estradiol. Predicted to be located in cell surface and extracellular matrix. Predicted to be active in Schaffer collateral - CA1 synapse; extracellular space; and glutamatergic synapse. Human ortholog(s) of this gene implicated in Fuhrmann syndrome and Schinzel type phocomelia. Orthologous to human WNT7A (Wnt family member 7A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wnt7a |
| Official Name | Wnt family member 7A [Source:RGD Symbol;Acc:69079] |
| Ensembl ID | ENSRNOG00000048782 |
| Bio databases IDs | |
| Aliases | Wnt family member 7A |
| Synonyms | px, SANTOS, tw, wingless-type MMTV integration site family, member 7A, Wnt family member 7A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wnt7a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt
- frizzled binding
- wnt family
- receptor agonist activity
- protein binding
- receptor binding
- cytokine
- found in Wnt-1
Pathways
Biological processes and signaling networks where the Wnt7a gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- neoplasia
- non-small cell lung cancer
- tumorigenesis
- squamous cell lung cancer
- severe limb deficiency, with absence of ulna and fibula
- hypoplasia of fibula
- pulmonary hypertensive arterial disease
role in cell
- activation
- expression in
- apoptosis
- morphology
- formation
- formation in
- differentiation
- remodeling
- migration
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- glutaminergic synapse
- endocytic vesicle membrane
- cell surface
- Plasma Membrane
- endoplasmic reticulum lumen
- synapse
- extracellular matrix
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wnt7a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to estrogen stimulus
- central nervous system vasculogenesis
- embryonic axis specification
- dorsal/ventral pattern formation
- embryonic digit morphogenesis
- positive regulation of protein metabolic process
- cartilage condensation
- positive regulation of transcription, DNA-dependent
- axonogenesis
- apoptotic process
- positive regulation of synapse assembly
- wound healing, spreading of epidermal cells
- embryonic forelimb morphogenesis
- embryonic hindlimb morphogenesis
- cerebellar granule cell differentiation
- neuron differentiation
- neurotransmitter secretion
- dendritic spine morphogenesis
- cellular response to transforming growth factor beta stimulus
- positive regulation of gene expression
- response to estradiol stimulus
- establishment of cell polarity
- negative regulation of neurogenesis
- oviduct development
- chondrocyte differentiation
- uterus morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- sex differentiation
- angiogenesis
- somatic stem cell division
- satellite cell activation
- somatic stem cell maintenance
- canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway, planar cell polarity pathway
- regulation of axon diameter
- satellite cell maintenance involved in skeletal muscle regeneration
- lens fiber cell development
- positive regulation of endothelial cell migration
- cell proliferation in forebrain
- positive regulation of epithelial cell proliferation involved in wound healing
- establishment of blood-brain barrier
- stem cell development
- asymmetric protein localization involved in cell fate determination
- negative regulation of apoptotic process
- positive regulation of JNK cascade
- cell fate commitment
- regulation of synaptic vesicle exocytosis
- positive regulation of excitatory postsynaptic membrane potential
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- extracellular matrix
- extracellular region
- Golgi lumen
- endocytic vesicle membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- protein binding
- receptor agonist activity
- cytokine activity
- receptor binding