Dusp9 Gene Summary [Rat]
Predicted to enable MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Predicted to be involved in negative regulation of ERK1 and ERK2 cascade and signal transduction. Predicted to act upstream of or within negative regulation of MAPK cascade. Predicted to be active in cytosol. Orthologous to human DUSP9 (dual specificity phosphatase 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dusp9 |
| Official Name | dual specificity phosphatase 9 [Source:RGD Symbol;Acc:1565535] |
| Ensembl ID | ENSRNOG00000055185 |
| Bio databases IDs | |
| Aliases | dual specificity phosphatase 9 |
| Synonyms | dual specificity phosphatase 9, MKP-4, Mpk4, Pyst3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dusp9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dual specificity phosphatase, catalytic domain
- protein tyrosine/serine/threonine phosphatase
- MAP kinase phosphatase
- protein-tyrosine-phoshatase
- protein phosphatase
- phosphoprotein phosphatase
- Rhodanese Homology Domain
- phosphatase
- protein binding
- PTP_DSP_cys
- RHOD
Pathways
Biological processes and signaling networks where the Dusp9 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- interstitial fibrosis
- diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- perivascular fibrosis
role in cell
- growth
- expression in
- cell death
- phosphorylation in
- differentiation
- G2/M phase
- adipogenesis
- surface area
- disruption
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dusp9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ERK1 and ERK2 cascade
- MAPK cascade
- negative regulation of MAPK cascade
- protein dephosphorylation
- JNK cascade
- peptidyl-tyrosine dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- phosphoprotein phosphatase activity
- protein binding
- MAP kinase tyrosine phosphatase activity
- protein tyrosine/threonine phosphatase activity
- MAP kinase tyrosine/serine/threonine phosphatase activity
- myosin phosphatase activity
- protein tyrosine/serine/threonine phosphatase activity