NTRK2 Gene Summary [Human]
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Details
| Type | Protein Coding |
| Official Symbol | NTRK2 |
| Official Name | neurotrophic receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:8032] |
| Ensembl ID | ENSG00000148053 |
| Bio databases IDs | |
| Aliases | neurotrophic receptor tyrosine kinase 2, BDNF/NT-3 growth factors receptor |
| Synonyms | AI848316, BDNF receptor, C030027L06RIK, DEE58, EIEE58, GP145-TrkB, GP145-TrkB/GP95-TrkB, Gp95 Trkb, neurotrophic receptor tyrosine kinase 2, neurotrophic tyrosine kinase, receptor, type 2, Nrh2, OBHD, RATTRKB1, Tkrb, TRKB, TRKB1, TRKB long isoform, Trkb receptor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NTRK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine rich repeat C-terminal motif
- neurotrophin p75 receptor
- Leucine rich repeat
- protein-tyrosine kinase
- Protein kinase domain
- IgG-C2 domain
- transmembrane receptor protein serine/threonine kinase
- cytoplasmic domain
- receptor tyrosine kinase binding
- Immunoglobulin like
- intracellular domain
- membrane-proximal domain
- Tyrosine kinase, catalytic domain
- cysteine rich domain
- Immunoglobulin V-set domain
- growth factor binding
- transmembrane receptor
- extracellular domain
- Protein kinase (unclassified specificity)
- leucine rich domain
- protease binding
- Protein tyrosine and serine/threonine kinase
- immunoglobulin domain
- ectodomain
- Immunoglobulin I-set domain
- Leucine rich repeat C-terminal domain
- protein binding
- phosphorylation site
- kinase
- PLC gamma binding domain
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Shc binding site
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- PLC gamma1 protein binding domain
- transmembrane domain
- tyrosine kinase domain
- protein homodimerization
- Leucine rich repeat N-terminal domain
Pathways
Biological processes and signaling networks where the NTRK2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- CDK5 Signaling
- Circadian Rhythm Signaling
- CREB Signaling in Neurons
- Docosahexaenoic Acid (DHA) Signaling
- Human Embryonic Stem Cell Pluripotency
- IL-15 Production
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Neurotrophin/TRK Signaling
- NF-κB Signaling
- PTEN Signaling
- Sperm Motility
- STAT3 Pathway
- Thyroid Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- metastatic non-small cell lung cancer
- advanced non-small cell lung cancer
- advanced non-small cell lung adenocarcinoma
- metastatic lung adenocarcinoma
- advanced large cell lung carcinoma
- non-squamous lung carcinoma
- metastatic large cell lung carcinoma
- malignant pleural mesothelioma
- hepatocellular carcinoma
role in cell
- expression in
- growth
- phosphorylation in
- activation in
- quantity
- apoptosis
- cell death
- expansion
- differentiation
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- soluble fraction
- postsynaptic density (PSD) fractions
- insoluble fractions
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- cell surface
- intracellular space
- perinuclear region
- postsynaptic region
- cellular membrane
- Nucleus
- endosomes
- vesicles
- Endoplasmic Reticulum
- Mitochondria
- microtubules
- cytosol
- presynaptic membrane
- postsynaptic membrane
- basolateral membrane
- Golgi membrane
- dendritic spines
- neuromuscular junctions
- growth cone
- neurites
- nerve ending
- axon initial segments
- dendrite initial segments
- synaptosomes
- synapse
- early endosomes
- membrane rafts
- filopodia
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- presynaptic terminals
- excitatory synapses
- melanin granules
- motor axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NTRK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutamate secretion
- multicellular organismal development
- positive regulation of cell proliferation
- feeding behavior
- protein autophosphorylation
- vasculogenesis
- central nervous system neuron development
- learning
- peripheral nervous system neuron development
- negative regulation of neuron apoptotic process
- cellular response to amino acid stimulus
- myelination in peripheral nervous system
- neuron migration
- positive regulation of axonogenesis
- negative regulation of anoikis
- long-term synaptic potentiation
- positive regulation of kinase activity
- positive regulation of neuron projection development
- positive regulation of synapse assembly
- neuronal action potential propagation
- positive regulation of peptidyl-serine phosphorylation
- oligodendrocyte differentiation
- neuron differentiation
- transmembrane receptor protein tyrosine kinase signaling pathway
- positive regulation of MAPK cascade
- cerebral cortex development
- circadian rhythm
- retinal rod cell development
- brain-derived neurotrophic factor receptor signaling pathway
- mechanoreceptor differentiation
- positive regulation of gene expression
- regulation of GTPase activity
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein phosphorylation
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- receptor complex
- axon terminus
- plasma membrane
- early endosome membrane
- dendrite
- early endosome
- perinuclear region of cytoplasm
- terminal button
- dendritic spine
- cytosol
- axon
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein homodimerization activity
- neurotrophin binding
- brain-derived neurotrophic factor-activated receptor activity
- brain-derived neurotrophic factor binding
- protease binding