Il1r1 Gene Summary [Mouse]
Enables interleukin-1 binding activity; interleukin-1 receptor activity; and protease binding activity. Involved in interleukin-1-mediated signaling pathway. Acts upstream of or within several processes, including cytokine-mediated signaling pathway; positive regulation of interleukin-1-mediated signaling pathway; and positive regulation of neutrophil extravasation. Located in external side of plasma membrane. Is expressed in aorta-gonad-mesonephros; brain; liver; spleen; and uterus. Used to study Sjogren's syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in chronic recurrent multifocal osteomyelitis; systemic scleroderma; and type 1 diabetes mellitus. Orthologous to human IL1R1 (interleukin 1 receptor type 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il1r1 |
| Official Name | interleukin 1 receptor, type I [Source:MGI Symbol;Acc:MGI:96545] |
| Ensembl ID | ENSMUSG00000026072 |
| Bio databases IDs | |
| Aliases | interleukin 1 receptor, type I |
| Synonyms | CD121A, CD121b, CRMO3, D2S1473, IL1bRa, IL1R, IL-1RA, IL-1R-alpha, IL-1RI, IL-1RT-1, IL-1R-α, IL-iR, INTERLEUKIN 1 beta receptor, interleukin 1 receptor type 1, interleukin 1 receptor, type I, INTERLEUKIN 1 β receptor, P80 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il1r1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protease binding
- immunoglobulin domain
- platelet-derived growth factor receptor binding
- SEFIR domain
- protein binding
- TIR domain
- interleukin-1 receptor
- interleukin-1 binding
- ionotropic glutamate receptor binding
- cytoplasmic domain
- interleukin-1, Type I, activating receptor
- Immunoglobulin like
- cytosolic tail domain
- membrane-proximal domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Il1r1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Agranulocyte Adhesion and Diapedesis
- FAK Signaling
- Glucocorticoid Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Cholestasis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HMGB1 Signaling
- IL-1 Signaling
- IL-10 Signaling
- IL-6 Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- Neuroinflammation Signaling Pathway
- NF-κB Signaling
- Osteoarthritis Pathway
- p38 MAPK Signaling
- PPAR Signaling
- PPARα/RXRα Activation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- obesity
- neoplasia
- pain
- acute alcoholic hepatitis
- systemic juvenile idiopathic arthritis
- polymyositis
- adult onset Still disease
- COVID-19
- Hutchinson-Gilford progeria syndrome
phenotypes
- abnormal cell death
- abnormal circulating serum amyloid protein level
- abnormal food intake
- abnormal inflammatory response
- abnormal lean body mass
- abnormal microglial cell activation
- abnormal nervous system electrophysiology
- abnormal neutrophil physiology
- abnormal response/metabolism to endogenous compounds
- abnormal vascular wound healing
- decreased T cell number
- decreased T cell proliferation
- decreased anxiety-related response
- decreased blood urea nitrogen level
- decreased circulating creatinine level
- decreased circulating interleukin-18 level
- decreased circulating interleukin-6 level
- decreased eosinophil cell number
- decreased immunoglobulin level
- decreased incidence of tumors by chemical induction
- decreased interleukin-6 secretion
- decreased neutrophil cell number
- decreased susceptibility to autoimmune diabetes
- decreased susceptibility to experimental autoimmune uveoretinitis
- decreased susceptibility to induced arthritis
- decreased susceptibility to kidney reperfusion injury
- decreased susceptibility to type IV hypersensitivity reaction
- decreased transforming growth factor level
- decreased tumor necrosis factor secretion
- delayed tooth eruption
- dental pulp necrosis
- enhanced contextual conditioning behavior
- enhanced wound healing
- hypoactivity
- impaired febrile response
- impaired glucose tolerance
- impaired neutrophil chemotaxis
- increased abdominal fat pad weight
- increased body length
- increased body mass index
- increased body weight
- increased bone resorption
- increased circulating insulin level
- increased circulating insulin-like growth factor I level
- increased circulating interleukin-1 beta level
- increased circulating interleukin-18 level
- increased circulating leptin level
- increased gonadal fat pad weight
- increased growth rate
- increased inguinal fat pad weight
- increased liver weight
- increased mesenteric fat pad weight
- increased percent body fat/body weight
- increased respiratory quotient
- increased retroperitoneal fat pad weight
- increased susceptibility to age related obesity
- increased susceptibility to bacterial infection
- increased susceptibility to bacterial infection induced morbidity/mortality
- increased susceptibility to induced arthritis
- increased total body fat amount
- insulin resistance
- no abnormal phenotype detected
- osteomyelitis
- sepsis
- weight loss
role in cell
- proliferation
- apoptosis
- expression in
- swelling
- cell death
- binding
- quantity
- phosphorylation in
- production in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- Extracellular Space
- intracellular space
- apical compartment
- perinuclear region
- cellular membrane
- cytosol
- plasma membrane extracellular face
- apical membrane
- neurites
- dendrite initial segments
- membrane processes
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il1r1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of neutrophil extravasation
- inflammatory response
- immune response
- positive regulation of interferon-gamma production
- response to interleukin-1
- regulation of inflammatory response
- positive regulation of T-helper 1 cell cytokine production
- cell surface receptor signaling pathway
- interleukin-1-mediated signaling pathway
- positive regulation of interleukin-1-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- external side of plasma membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- NAD+ nucleosidase activity
- protein binding
- transmembrane signaling receptor activity
- platelet-derived growth factor receptor binding
- protease binding
- interleukin-1 receptor activity
- interleukin-1, Type I, activating receptor activity
- interleukin-1 binding