Sigirr Gene Summary [Mouse]
Involved in acute-phase response; negative regulation of chemokine production; and negative regulation of interleukin-1-mediated signaling pathway. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. Is expressed in male reproductive system and urinary system. Orthologous to human SIGIRR (single Ig and TIR domain containing). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sigirr |
| Official Name | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain [Source:MGI Symbol;Acc:MGI:1344402] |
| Ensembl ID | ENSMUSG00000025494 |
| Bio databases IDs | |
| Aliases | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain |
| Synonyms | IL-1R8, LOC100294402, LOC100510338, RGD1306732, single Ig and TIR domain containing, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, TIR8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sigirr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoglobulin domain
- Immunoglobulin like
- SEFIR domain
- Immunoglobulin I-set domain
- protein binding
- TIR domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Sigirr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight loss
- diabetes mellitus
- neoplastic cell transformation
- cancer
- psoriasis
- androgenic alopecia
- colitis
- psoriatic lesion
- bleeding
- acute renal failure
role in cell
- expression in
- activation in
- phosphorylation in
- proliferation
- activation
- quantity
- transactivation in
- expansion
- permeability
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sigirr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cytokine-mediated signaling pathway
- signal transduction
- negative regulation of chemokine production
- negative regulation of Toll signaling pathway
- acute-phase response
- negative regulation of lipopolysaccharide-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding