MATK Gene Summary [Human]
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MATK |
| Official Name | megakaryocyte-associated tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6906] |
| Ensembl ID | ENSG00000007264 |
| Bio databases IDs | |
| Aliases | megakaryocyte-associated tyrosine kinase, Csk-homologous kinase, tyrosine-protein kinase CTK, protein kinase HYL, hematopoietic consensus tyrosine-lacking kinase, tyrosylprotein kinase, hydroxyaryl-protein kinase, Csk-type protein tyrosine kinase, HYL tyrosine kinase, tyrosine kinase MATK, leukocyte carboxyl-terminal src kinase related |
| Synonyms | Batk, CHK, CTK, HHYLTK, HYL, HYLTK, Lsk, megakaryocyte-associated tyrosine kinase, Ntk, p56ntk |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MATK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- ATP-binding domain
- Src homology 2 (SH2) domain
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- Tyrosine kinase, catalytic domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the MATK gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pervasive developmental disorder
- cutaneous melanoma
- cutaneous melanoma cancer
- insulin resistance
- tumorigenesis
- primary Sjögren syndrome
role in cell
- expression in
- formation
- quantity
- proliferation
- activation in
- number
- outgrowth
- phosphorylation in
- growth
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- membrane fraction
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MATK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- non-membrane spanning protein tyrosine kinase activity