FOXN3 Gene Summary [Human]
This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FOXN3 |
| Official Name | forkhead box N3 [Source:HGNC Symbol;Acc:HGNC:1928] |
| Ensembl ID | ENSG00000053254 |
| Bio databases IDs | |
| Aliases | forkhead box N3 |
| Synonyms | 5430426H20Rik, AW556347, C14ORF116, CHES1, CHES1L, forkhead box N3, HTLFL1, LOC100039892, PRO1635 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FOXN3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- SKIP-binding domain
- FH_FOX
- Sin3 binding domain
- protein binding
- Forkhead domain
- FORKHEAD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ischemic stroke
- Huntington disease
- acute myeloid leukemia
- non-insulin-dependent diabetes mellitus
- idiopathic intracranial hypertension
- small cell lung carcinoma
- small cell lung cancer
- ovarian carcinoma
- epithelial ovarian cancer
- hepatic fibrosis
role in cell
- proliferation
- expression in
- phosphorylation in
- G2/M phase
- transcription in
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FOXN3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle G2/M transition DNA damage checkpoint
- negative regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- craniofacial suture morphogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity