MAP3K13 Gene Summary [Human]
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MAP3K13 |
| Official Name | mitogen-activated protein kinase kinase kinase 13 [Source:HGNC Symbol;Acc:HGNC:6852] |
| Ensembl ID | ENSG00000073803 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase 13, leucine zipper-bearing kinase |
| Synonyms | 1300002E11RIK, C130026N12RIK, LOC100505749, LZK, MEKK13, mitogen-activated protein kinase kinase kinase 13, MLK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP3K13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- enzyme binding
- leucine zipper domain
- protein binding
- Protein kinase domain
- identical protein binding
- MAP kinase kinase kinase
- kinase
- protein kinase activator
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- binding protein
- Protein Kinases, catalytic domain
- protein homodimerization
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the MAP3K13 gene in human plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Cardiac Hypertrophy Signaling
- CD27 Signaling in Lymphocytes
- G-Protein Coupled Receptor Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- GNRH Signaling
- HGF Signaling
- Natural Killer Cell Signaling
- NGF Signaling
- PKCθ Signaling in T Lymphocytes
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- RANK Signaling in Osteoclasts
- SAPK/JNK Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cell cortex
- membrane compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP3K13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JUN kinase activity
- positive regulation of neuron maturation
- protein autophosphorylation
- positive regulation of axon extension
- JNK cascade
- protein phosphorylation
- peptidyl-serine phosphorylation
- positive regulation of NF-kappaB transcription factor activity
- stress-activated MAPK cascade
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- identical protein binding
- protein binding
- protein serine/threonine kinase activator activity
- protein homodimerization activity
- metal ion binding
- JUN kinase kinase kinase activity
- MAP kinase kinase kinase activity
- protein serine/threonine kinase activity
- enzyme binding