CDC14A Gene Summary [Human]
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | CDC14A |
| Official Name | cell division cycle 14A [Source:HGNC Symbol;Acc:HGNC:1718] |
| Ensembl ID | ENSG00000079335 |
| Bio databases IDs | |
| Aliases | cell division cycle 14A |
| Synonyms | A830059A17RIK, CD14, CDC14, CDC14a1, CDC14A2, CDC14 cell division cycle 14A, cell division cycle 14A, DFNB105, DFNB32, DFNB35, hCDC14 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDC14A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dual specificity phosphatase, catalytic domain
- nuclear export signal
- plk1 phosphorylation site
- protein serine/threonine phosphatase
- phosphatase
- PTP_DSP_cys
- protein binding
- phosphatase domain
- Dual specificity protein phosphatase, N-terminal half
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- alcoholism
- teratozoospermia
- colorectal carcinomagenesis
- organismal death
- breast adenocarcinoma
- infertile male syndrome with hearing impairment
- autosomal recessive deafness type 105
- diarrhea
- breast carcinoma
- chronic lymphocytic leukemia
role in cell
- expression in
- cell death
- quantity
- length
- phosphorylation in
- growth
- formation
- formation in
- mitosis
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- kinocilia
- Cytoplasm
- actin cytoskeleton
- basal bodies
- centrosome
- Endoplasmic Reticulum
- midbody
- cytosol
- stereocilia
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDC14A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- cell division
- cilium morphogenesis
- regulation of exit from mitosis
- microtubule cytoskeleton organization
- positive regulation of cytokinesis
Cellular Component
Where in the cell the gene product is active
- centrosome
- nuclear body
- mitotic spindle
- cytoplasm
- spindle pole
- kinocilium
- cytosol
- nucleolus
- stereocilium bundle tip
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- protein tyrosine phosphatase activity
- myosin phosphatase activity