CCNT2 Gene Summary [Human]
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | CCNT2 |
| Official Name | cyclin T2 [Source:HGNC Symbol;Acc:HGNC:1600] |
| Ensembl ID | ENSG00000082258 |
| Bio databases IDs | |
| Aliases | cyclin T2 |
| Synonyms | 2900041I18Rik, Cyclin T2, CYCT2, CycT2a, CycT2b, P-FEBb |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCNT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- snRNA binding
- transcription regulator
- protein kinase binding
- Cyclin box fold superfamily
- enzyme binding
- transcription factor binding
- chromatin binding
- Cyclin, N-terminal domain
- protein binding
- domain present in cyclins, TFIIB and Retinoblastoma
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic lymphocytic leukemia
role in cell
- expression in
- differentiation
- mineralization
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- perinuclear region
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCNT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- immediate early viral mRNA transcription
- late viral mRNA transcription
- skeletal muscle tissue development
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription elongation, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
- regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytosol
- positive transcription elongation factor complex b
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase binding
- protein binding
- chromatin binding
- transcription coactivator binding