NFKBIB Gene Summary [Human]
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]
Details
| Type | Protein Coding |
| Official Symbol | NFKBIB |
| Official Name | NFKB inhibitor beta [Source:HGNC Symbol;Acc:HGNC:7798] |
| Ensembl ID | ENSG00000104825 |
| Bio databases IDs | |
| Aliases | NFKB inhibitor beta, NF-kappa-B inhibitor beta |
| Synonyms | I-kappa-B-beta, I(Kappa)B(beta), I kappa B β, IkB, IKBB, IKB-beta, IKB-β, I-κ-B-β, I(κ)B(β), NF-kappa-BIB, NFKB inhibitor beta, NFKB inhibitor β, NF-κ-BIB, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta, nuclear factor of κ light polypeptide gene enhancer in B cells inhibitor, β, TRIP9 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NFKBIB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PEST domain
- transcription regulator
- Ankyrin repeats (many copies)
- transcription co-activator
- Ankyrin repeats (3 copies)
- protein binding
- Ankyrin repeat
- phosphorylation site
- ankyrin repeats
Pathways
Biological processes and signaling networks where the NFKBIB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- asthma
- disease-free survival
- dermatitis
- obesity
- collagen-induced arthritis
- osteolysis
- septic shock
- endotoxin shock response
- granulocytosis
role in cell
- formation
- expression in
- production in
- necrosis
- cell death
- apoptosis
- growth
- transactivation in
- survival
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- soluble fraction
- Cytoplasm
- lysosome
- cytosol
- microsome
- lysosome membrane
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NFKBIB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- cellular response to lipopolysaccharide
- transcription, DNA-dependent
- signal transduction
- positive regulation of transcription, DNA-dependent
- regulation of I-kappaB kinase/NF-kappaB cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity