MARK1 Gene Summary [Human]
Enables several functions, including ATP binding activity; phospholipid binding activity; and protein kinase activity. Involved in intracellular signal transduction and protein phosphorylation. Located in cytoplasm; dendrite; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MARK1 |
| Official Name | microtubule affinity regulating kinase 1 [Source:HGNC Symbol;Acc:HGNC:6896] |
| Ensembl ID | ENSG00000116141 |
| Bio databases IDs | |
| Aliases | microtubule affinity regulating kinase 1 |
| Synonyms | B930025N23Rik, Emk3, MAP/microtubule affinity regulating kinase 1, MARK, microtubule affinity regulating kinase 1, mKIAA1477, mPar-1c, PAR1C |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MARK1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- phospholipid binding
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Kinase regulatory loop binding domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- magnesium ion binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Tau-protein kinase
- binding protein
- Protein Kinases, catalytic domain
- AMPKA_C_like
- Kinase associated domain 1
- phosphatidylinositol-4,5-bisphosphate binding
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the MARK1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peripheral arterial disease
- Kawasaki disease
role in cell
- expression in
- migration
- development
- alternative splicing in
- organization
- signal transduction in
- polarity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- microtubule cytoskeleton
- cytoskeleton
- postsynaptic region
- Plasma Membrane
- growth cone
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MARK1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- microtubule cytoskeleton organization
- protein phosphorylation
- regulation of dendrite development
- negative regulation of gene expression
- establishment of mitochondrion localization
- neuron migration
- negative regulation of epithelial to mesenchymal transition
- positive regulation of gene expression
- Wnt receptor signaling pathway
- regulation of neuron projection development
- peptidyl-serine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- dendrite
- microtubule cytoskeleton
- cytoskeleton
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- tau-protein kinase activity
- magnesium ion binding
- ATP binding
- phosphatidylinositol-4,5-bisphosphate binding
- phosphatidylserine binding
- protein binding
- tau protein binding
- phosphatidic acid binding
- protein serine/threonine kinase activity