RHOU Gene Summary [Human]
This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.[provided by RefSeq, Mar 2011]
Details
| Type | Protein Coding |
| Official Symbol | RHOU |
| Official Name | ras homolog family member U [Source:HGNC Symbol;Acc:HGNC:17794] |
| Ensembl ID | ENSG00000116574 |
| Bio databases IDs | |
| Aliases | ras homolog family member U, Ryu GTPase, Wnt-1 responsive Cdc42 homolog, 2310026M05Rik, GTP-binding protein like 1, CDC42-like GTPase, GTP-binding protein SB128, ras-like gene family member U |
| Synonyms | 2310026M05Rik, ARHU, CDC42L1, G28K, hG28K, LOC678766, mG28K, ras homolog family member U, Rhoul1, WRCH-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RHOU often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- effector loop
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- proline rich domain
- Ras subfamily of RAS small GTPases
- small GTP-binding protein domain
- guanyl-nucleotide exchange factor
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the RHOU gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- adenomyosis
- T acute lymphoblastic leukemia
- chronic lymphocytic leukemia
- autosomal dominant polycystic kidney disease
role in cell
- expression in
- migration
- G1/S phase transition
- adhesion
- proliferation
- dissociation
- growth
- formation
- organization
- turnover in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
- endosomal membrane
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RHOU gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Rac protein signal transduction
- regulation of cell shape
- cytoskeleton organization
- regulation of small GTPase mediated signal transduction
- establishment or maintenance of cell polarity
- G1/S transition of mitotic cell cycle
- actin filament organization
- Cdc42 protein signal transduction
- endocytosis
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytosol
- Golgi membrane
- endosome membrane
- cell projection
- plasma membrane
- podosome
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein kinase binding
- protein binding
- metal ion binding
- GTPase activity
- guanyl-nucleotide exchange factor activity