Mettl16 Gene Summary [Mouse]
Enables mRNA m(6)A methyltransferase activity. Involved in RNA metabolic process and mRNA destabilization. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system. Orthologous to human METTL16 (methyltransferase 16, RNA N6-adenosine). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mettl16 |
| Official Name | methyltransferase like 16 [Source:MGI Symbol;Acc:MGI:1914743] |
| Ensembl ID | ENSMUSG00000010554 |
| Bio databases IDs | |
| Aliases | methyltransferase like 16 |
| Synonyms | 2610100D03Rik, 2810013M15RIK, A830095F14RIK, AI846133, methyltransferase 16, N6-methyladenosine, methyltransferase 16, RNA N6-adenosine, METT10D |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mettl16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA (N6-adenosine)-methyltransferase
- RNA methyltransferase
- U6 snRNA 3' end binding
- enzyme
- AdoMet_MTases
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- melanoma cancer
- cancer
- insomnia
- epithelial neoplasia
- epithelial cancer
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
role in cell
- phosphorylation in
- expression in
- proliferation
- migration
- invasion by
- colony formation
- growth
- JQ1 resistance
- translation in
- maturation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mettl16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- posttranscriptional regulation of gene expression
- mRNA destabilization
- rRNA base methylation
- regulation of nuclear mRNA splicing, via spliceosome
- mRNA processing
- S-adenosylmethionine biosynthetic process
- mRNA catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- mRNA (N6-adenosine)-methyltransferase activity
- U6 snRNA 3'-end binding
- 23S rRNA (adenine(1618)-N(6))-methyltransferase activity
- RNA stem-loop binding