AJUBA Gene Summary [Human]
Enables alpha-catenin binding activity and transcription corepressor activity. Involved in several processes, including negative regulation of hippo signaling; positive regulation of gene silencing by miRNA; and regulation of cellular response to hypoxia. Acts upstream of or within gene silencing by miRNA and positive regulation of protein-containing complex assembly. Located in several cellular components, including Golgi apparatus; P-body; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | AJUBA |
| Official Name | ajuba LIM protein [Source:HGNC Symbol;Acc:HGNC:20250] |
| Ensembl ID | ENSG00000129474 |
| Bio databases IDs | |
| Aliases | ajuba LIM protein |
| Synonyms | ajuba LIM protein, JUB |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AJUBA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- actin filament binding
- PreLIM domain
- transcription regulator
- alpha-catenin binding
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- transcription co-repressor
- CoRNR motif
- chromatin binding
- protein binding
Pathways
Biological processes and signaling networks where the AJUBA gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- open-angle glaucoma
- lung adenocarcinoma
- lung adenocarcinoma formation
- renal clear cell adenocarcinoma
- renal clear cell cancer
- colorectal adenoma
- colorectal adenoma formation
- breast adenocarcinoma
- urothelial bladder carcinoma
role in cell
- formation
- expression in
- proliferation
- growth
- differentiation
- binding in
- migration
- function
- assembly
- mitosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic mRNA processing body
- Cytoplasm
- cell surface
- focal adhesions
- centrosome
- Golgi Apparatus
- intercellular junctions
- cytosol
- nucleoplasm
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AJUBA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of hippo signaling cascade
- calcium-dependent cell-cell adhesion
- negative regulation of translation involved in gene silencing by miRNA
- cytoskeleton organization
- gene silencing by miRNA
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- protein localization
- regulation of transcription, DNA-dependent
- regulation of cellular response to hypoxia
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of cellular biosynthetic process
- response to hypoxia
- glycerophospholipid biosynthetic process
- lamellipodium assembly
- focal adhesion assembly
- regulation of cell migration
- wound healing, spreading of epidermal cells
- positive regulation of protein complex assembly
Cellular Component
Where in the cell the gene product is active
- cytoplasmic mRNA processing body
- Golgi apparatus
- plasma membrane
- nucleoplasm
- nucleus
- transcription factor complex
- centrosome
- adherens junction
- cell-cell junction
- focal adhesion
- cytosol
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- alpha-catenin binding
- protein binding
- transcription corepressor activity
- metal ion binding
- protein kinase activator activity
- chromatin binding