GPS2 Gene Summary [Human]
This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GPS2 |
| Official Name | G protein pathway suppressor 2 [Source:HGNC Symbol;Acc:HGNC:4550] |
| Ensembl ID | ENSG00000132522 |
| Bio databases IDs | |
| Aliases | G protein pathway suppressor 2 |
| Synonyms | AMF-1, G protein pathway suppressor 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA Pol II CTD binding domain
- transcription regulator
- transcription co-activator
- GTPase inhibitor
- UDM1_RNF168_RNF169-like
- transcription co-repressor
- G-protein pathway suppressor
- coiled-coil domain
- protein binding
- cyclin binding
Pathways
Biological processes and signaling networks where the GPS2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- hepatic steatosis
- anemia
role in cell
- expression in
- quantity
- activation in
- phosphorylation in
- differentiation
- proliferation
- binding in
- replication in
- degradation in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPS2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B cell differentiation
- positive regulation of peroxisome proliferator activated receptor signaling pathway
- negative regulation of toll-like receptor signaling pathway
- negative regulation of inflammatory response
- negative regulation of protein K63-linked ubiquitination
- negative regulation of fat cell differentiation
- JNK cascade
- regulation of fat cell differentiation
- negative regulation of JNK cascade
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of tumor necrosis factor-mediated signaling pathway
- positive regulation of cholesterol efflux
- negative regulation of B cell receptor signaling pathway
- regulation of lipid metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- transcriptional repressor complex
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor activity
- protein binding
- transcription coactivator activity
- GTPase inhibitor activity
- transcription corepressor activity
- cyclin binding