IFNW1 Gene Summary [Human]
The protein encoded by this gene is an interferon and possesses antiviral activity. The encoded protein binds to the interferon alpha/beta receptor but not to the interferon gamma receptor. This intronless gene has several pseudogenes spread throughout the genome. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | IFNW1 |
| Official Name | interferon omega 1 [Source:HGNC Symbol;Acc:HGNC:5448] |
| Ensembl ID | ENSG00000177047 |
| Bio databases IDs | |
| Aliases | interferon omega 1, IFN-omega 1, interferon omega-1 |
| Synonyms | IFN-OMEGA, IFN-ω, interferon omega 1, interferon ω 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IFNW1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- IFab
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the IFNW1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Glucocorticoid Receptor Signaling
- IL-12 Signaling and Production in Macrophages
- Retinoic acid Mediated Apoptosis Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- Role of PKR in Interferon Induction and Antiviral Response
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- psoriasis
- weight loss
role in cell
- phosphorylation in
- expression in
- activation in
- cell death
- production in
- apoptosis
- proliferation
- differentiation
- activation
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IFNW1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B cell differentiation
- positive regulation of peptidyl-serine phosphorylation of STAT protein
- B cell proliferation
- adaptive immune response
- response to virus
- T cell activation involved in immune response
- type I interferon-mediated signaling pathway
- natural killer cell activation involved in immune response
- cytokine-mediated signaling pathway
- response to exogenous dsRNA
- humoral immune response
- defense response to virus
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- interferon-alpha/beta receptor binding
- cytokine activity
- cytokine receptor binding