LECT2 Gene Summary [Human]
This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LECT2 |
| Official Name | leukocyte cell derived chemotaxin 2 [Source:HGNC Symbol;Acc:HGNC:6550] |
| Ensembl ID | ENSG00000145826 |
| Bio databases IDs | |
| Aliases | leukocyte cell derived chemotaxin 2 |
| Synonyms | chm2, chm-II, leukocyte cell-derived chemotaxin 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LECT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidase family M23
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- liver cancer
- collagen-induced arthritis
- cryptogenic cirrhosis
- hepatitis C virus and schistosomiasis-related cirrhosis
- autoimmune hepatitis-related cirrhosis
- primary biliary cirrhosis
- hepatocellular carcinoma
- hepatitis B virus-related liver cirrhosis
role in cell
- expression in
- apoptosis
- activation
- number
- production in
- binding in
- killing
- migration
- phagocytosis
- clearance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LECT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- skeletal system development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding