MAP3K6 Gene Summary [Human]
This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | MAP3K6 |
| Official Name | mitogen-activated protein kinase kinase kinase 6 [Source:HGNC Symbol;Acc:HGNC:6858] |
| Ensembl ID | ENSG00000142733 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase 6, apoptosis signal regulating kinase 2 |
| Synonyms | ASK2, MAPKKK6, MEKK6, mitogen-activated protein kinase kinase kinase 6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP3K6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- HisK-N-like globin domain of the ASK signalosome
- ATP binding
- protein binding
- magnesium ion binding
- Protein kinase domain
- MAP kinase kinase kinase
- kinase
- Serine/Threonine protein kinases, catalytic domain
- ASK kinase PH domain
- MAP3K TRAFs-binding domain
- Protein Kinases, catalytic domain
- Tetratricopeptide Repeats-Sensor
- alcohol group acceptor phosphotransferase
- Deoxyribohydrolase (DRHyd) domain of the ASK signalosome
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the MAP3K6 gene in human plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Cardiac Hypertrophy Signaling
- CD27 Signaling in Lymphocytes
- G-Protein Coupled Receptor Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- GNRH Signaling
- HGF Signaling
- Natural Killer Cell Signaling
- NGF Signaling
- PKCθ Signaling in T Lymphocytes
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- RANK Signaling in Osteoclasts
- Sertoli Cell-Sertoli Cell Junction Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
role in cell
- expression in
- production in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP3K6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- signal transduction
- cellular response to stress
- protein phosphorylation
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein binding
- MAP kinase kinase kinase activity