NFKBIE Gene Summary [Human]
The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | NFKBIE |
| Official Name | NFKB inhibitor epsilon [Source:HGNC Symbol;Acc:HGNC:7799] |
| Ensembl ID | ENSG00000146232 |
| Bio databases IDs | |
| Aliases | NFKB inhibitor epsilon, NF-kappa-B inhibitor epsilon |
| Synonyms | I-kappa-B-epsilon, IKBE, ikB-epsilon, ikB-ε, I-κ-B-ε, NF-kappa-BIE, NFKB inhibitor epsilon, NFKB inhibitor ε, NF-κ-BIE, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon, nuclear factor of κ light polypeptide gene enhancer in B cells inhibitor, ε, Slc35b2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NFKBIE often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- Ankyrin repeats (3 copies)
- protein binding
- Ankyrin repeat
- ankyrin repeats
Pathways
Biological processes and signaling networks where the NFKBIE gene in human plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- Angiopoietin Signaling
- April Mediated Signaling
- B Cell Activating Factor Signaling
- CD27 Signaling in Lymphocytes
- Dendritic Cell Maturation
- Glucocorticoid Receptor Signaling
- HER-2 Signaling in Breast Cancer
- Hypoxia Signaling in the Cardiovascular System
- Induction of Apoptosis by HIV1
- LPS-stimulated MAPK Signaling
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- Molecular Mechanisms of Cancer
- NF-κB Activation by Viruses
- NF-κB Signaling
- PEDF Signaling
- Prostate Cancer Signaling
- Protein Kinase A Signaling
- RANK Signaling in Osteoclasts
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of IL-17A in Arthritis
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- Small Cell Lung Cancer Signaling
- TNFR1 Signaling
- TNFR2 Signaling
- TWEAK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nodular sclerosis classical Hodgkin lymphoma
- nodular sclerosis Hodgkin disease
- breast carcinoma
- rheumatoid arthritis
- Waldenström macroglobulinemia
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- chronic form of lymphocytic leukemia
- Marfan syndrome
- mixed cellularity classical Hodgkin lymphoma
- mixed cell Hodgkin disease
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- Cytoplasm
- perinuclear region
- cytosol
- nucleoplasm
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NFKBIE gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic sequestering of transcription factor
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding