TPBG Gene Summary [Human]
This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | TPBG |
| Official Name | trophoblast glycoprotein [Source:HGNC Symbol;Acc:HGNC:12004] |
| Ensembl ID | ENSG00000146242 |
| Bio databases IDs | |
| Aliases | trophoblast glycoprotein |
| Synonyms | 5T4, 5T4AG, M6P1, trophoblast glycoprotein, WAIF1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TPBG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- Leucine rich repeat N-terminal domain
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine leiomyoma
- preeclampsia
- leiomyomatosis
- renal cell carcinoma
- Parkinson disease
role in cell
- proliferation
- invasion by
- arborization
- motility
- chemotaxis
- arborization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- growth cone
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TPBG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of cell proliferation
- positive regulation of ERK1 and ERK2 cascade
- cell adhesion
- olfactory learning
- positive regulation of synapse assembly
- synaptic transmission, GABAergic
- positive regulation of chemotaxis
- positive regulation of protein kinase B signaling cascade
- protein localization in plasma membrane
- cell chemotaxis
Cellular Component
Where in the cell the gene product is active
- dendrite
- endoplasmic reticulum
- plasma membrane
- axon terminus
- cell surface