ADGRF1 Gene Summary [Human]
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within several processes, including memory; nervous system development; and positive regulation of CREB transcription factor activity. Predicted to be located in extracellular region and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ADGRF1 |
| Official Name | adhesion G protein-coupled receptor F1 [Source:HGNC Symbol;Acc:HGNC:18990] |
| Ensembl ID | ENSG00000153292 |
| Bio databases IDs | |
| Aliases | adhesion G protein-coupled receptor F1 |
| Synonyms | 5031409J19RIK, adhesion G protein-coupled receptor F1, FLJ22684, GPR110, hGPCR36, KPG 009, KPG 012, PGR19 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADGRF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 7 transmembrane receptor (Secretin family)
- SEA domain
- GPCR proteolysis site, GPS, motif
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the ADGRF1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- EGFR mutation positive adenocarcinoma of the lung
- EGFR mutation positive non-small cell lung cancer
- lung adenocarcinoma formation
- EGFR expression positive non-squamous non-small cell lung cancer
- primary pulmonary hypertension
role in cell
- assembly
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADGRF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synapse assembly
- G-protein coupled receptor signaling pathway
- neuron projection development
- energy reserve metabolic process
- cell surface receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- fat cell differentiation
- regulation of lipid metabolic process
- memory
Cellular Component
Where in the cell the gene product is active
- membrane
- cytoplasmic vesicle
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding