Adgrf1 Gene Summary [Mouse]
Enables G protein-coupled receptor activity. Acts upstream of or within several processes, including memory; nervous system development; and positive regulation of CREB transcription factor activity. Located in plasma membrane. Is expressed in adrenal gland; liver; and metanephros. Orthologous to human ADGRF1 (adhesion G protein-coupled receptor F1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adgrf1 |
| Official Name | adhesion G protein-coupled receptor F1 [Source:MGI Symbol;Acc:MGI:1924846] |
| Ensembl ID | ENSMUSG00000041293 |
| Bio databases IDs | |
| Aliases | adhesion G protein-coupled receptor F1 |
| Synonyms | 5031409J19RIK, adhesion G protein-coupled receptor F1, FLJ22684, GPR110, hGPCR36, KPG 009, KPG 012, PGR19 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adgrf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 7 transmembrane receptor (Secretin family)
- SEA domain
- GPCR proteolysis site, GPS, motif
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Adgrf1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- EGFR mutation positive adenocarcinoma of the lung
- EGFR mutation positive non-small cell lung cancer
- lung adenocarcinoma formation
- EGFR expression positive non-squamous non-small cell lung cancer
- primary pulmonary hypertension
role in cell
- assembly
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adgrf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synapse assembly
- G-protein coupled receptor signaling pathway
- neuron projection development
- energy reserve metabolic process
- cell surface receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- fat cell differentiation
- regulation of lipid metabolic process
- memory
Cellular Component
Where in the cell the gene product is active
- membrane
- cytoplasmic vesicle
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding