SGO2 Gene Summary [Human]
Predicted to be involved in homologous chromosome segregation; meiotic sister chromatid cohesion; and mitotic sister chromatid segregation. Predicted to act upstream of or within meiotic nuclear division; positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric; and protein localization. Located in chromosome, centromeric region and nuclear body. Part of mitotic cohesin complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SGO2 |
| Official Name | shugoshin 2 [Source:HGNC Symbol;Acc:HGNC:30812] |
| Ensembl ID | ENSG00000163535 |
| Bio databases IDs | |
| Aliases | shugoshin 2 |
| Synonyms | 1110007N04Rik, 4932411A20Rik, 5730576N04Rik, D1Ertd8e, Sgo2a, SGOL2, Sgol2a, shugoshin 2, shugoshin 2A, TRIPIN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SGO2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- central domain
- coiled-coil domain
- protein binding
- Shugoshin C terminus
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- premature ovarian failure
- lung adenocarcinoma
- lung adenocarcinoma formation
- gonadal dysgenesis with auditory dysfunction, autosomal recessive inheritance
- organismal death
role in cell
- expression in
- proliferation
- migration
- colony formation
- invasion by
- molecular cleavage in
- cohesion in
- cohesion
- meiosis
- chromosomal congression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
- kinetochores
- centromeres
- chromosomal arms
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SGO2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- meiotic cell cycle
- meiotic sister chromatid cohesion
- chromosome segregation
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cytosol
- kinetochore
- mitotic cohesin complex
- chromosome, centromeric region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding