LPAR3 Gene Summary [Human]
This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LPAR3 |
| Official Name | lysophosphatidic acid receptor 3 [Source:HGNC Symbol;Acc:HGNC:14298] |
| Ensembl ID | ENSG00000171517 |
| Bio databases IDs | |
| Aliases | lysophosphatidic acid receptor 3 |
| Synonyms | EDG7, GPCR, HOFNH30, LP-A3, LPA3 receptor, LPA receptor 3, lysophosphatidic acid receptor 3, RP4-678I3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LPAR3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- phospholipid binding
- lipid binding
- 7 transmembrane receptor (rhodopsin family)
- tail domain
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the LPAR3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- acute myeloid leukemia
- chronic obstructive pulmonary disease
- diabetic nephropathy
- latent tuberculosis
- androgenic alopecia
- insulin-dependent diabetes mellitus
role in cell
- expression in
- formation
- chemotaxis
- proliferation
- recruitment
- transepithelial electrical resistance
- formation by
- accumulation in
- elevation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cilia
- cell surface
- perinuclear membrane
- cellular membrane
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LPAR3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of collateral sprouting
- bleb assembly
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- collateral sprouting
- regulation of metabolic process
- gene expression
- synaptic transmission
- positive regulation of MAPK cascade
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- synapse
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- lysophosphatidic acid receptor activity
- G-protein coupled receptor activity
- protein binding
- lipid binding