PIK3CD Gene Summary [Human]
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]
Details
| Type | Protein Coding |
| Official Symbol | PIK3CD |
| Official Name | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [Source:HGNC Symbol;Acc:HGNC:8977] |
| Ensembl ID | ENSG00000171608 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta, phosphatidylinositol 3-kinase, catalytic, delta polypeptide, phosphoinositide-3-kinase C |
| Synonyms | 2410099E07Rik, 2610208K16RIK, APDS, IMD14, IMD14A, IMD14B, p110D, P110DELTA, P110 δ, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit δ, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit δ, PI3K, PI3K-delta, PI3K δ, ROCHIS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PIK3CD often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- PI3-kinase family, p85-binding domain
- phosphatidylinositol 3-kinase
- Phosphoinositide 3-kinase, catalytic domain
- Protein Kinases, catalytic domain
- Phosphatidylinositol 3- and 4-kinase
- Ras-binding domain
- phosphatidylinositol-4,5-bisphosphate 3-kinase
- protein binding
- PI3-kinase family, ras-binding domain
- C2 domain
- PI3Ka
Pathways
Biological processes and signaling networks where the PIK3CD gene in human plays a role, providing insight into its function and relevance in health or disease.
- Angiopoietin Signaling
- Apelin Cardiomyocyte Signaling Pathway
- Cancer Drug Resistance By Drug Efflux
- CCR3 Signaling in Eosinophils
- Clathrin-mediated Endocytosis Signaling
- CNTF Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- ErbB Signaling
- ErbB4 Signaling
- Glucocorticoid Receptor Signaling
- Growth Hormone Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-9 Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- Mouse Embryonic Stem Cell Pluripotency
- MSP-RON Signaling Pathway
- Neurotrophin/TRK Signaling
- NGF Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- p53 Signaling
- PDGF Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Th2 Pathway
- Thyroid Cancer Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- allergic rhinitis
- lymphoma
- asthma
- inflammatory bowel disease
- prostate cancer
- peripheral T-cell lymphoma
- liver cancer
- tumorigenesis
role in cell
- expression in
- phosphorylation in
- differentiation
- apoptosis
- activity
- formation
- formation in
- aggregation
- proliferation
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear Golgi regions
- Plasma Membrane
- cytosol
- Golgi buds
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PIK3CD gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell activation
- phosphatidylinositol-3-phosphate biosynthetic process
- B cell activation
- mast cell degranulation
- protein phosphorylation
- positive regulation of angiogenesis
- inflammatory response
- protein kinase B signaling cascade
- T cell chemotaxis
- immune response
- respiratory burst involved in defense response
- natural killer cell activation
- phosphorylation
- cell migration
- positive regulation of endothelial cell migration
- B cell chemotaxis
- T cell receptor signaling pathway
- B cell receptor signaling pathway
- mast cell differentiation
- B cell differentiation
- signal transduction
- positive regulation of neutrophil apoptotic process
- vascular endothelial growth factor signaling pathway
- adaptive immune response
- mast cell chemotaxis
- T cell differentiation
- phosphatidylinositol-mediated signaling
- innate immune response
- positive regulation of gene expression
- natural killer cell differentiation
- neutrophil extravasation
- neutrophil chemotaxis
- natural killer cell chemotaxis
- positive regulation of endothelial cell proliferation
- positive regulation of cytokine production
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex
- phosphatidylinositol 3-kinase complex
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- phosphatidylinositol-4,5-bisphosphate 3-kinase activity
- 1-phosphatidylinositol-4-phosphate 3-kinase activity
- kinase activity
- 1-phosphatidylinositol-3-kinase activity