LIN9 Gene Summary [Human]
This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | LIN9 |
| Official Name | lin-9 DREAM MuvB core complex component [Source:HGNC Symbol;Acc:HGNC:30830] |
| Ensembl ID | ENSG00000183814 |
| Bio databases IDs | |
| Aliases | lin-9 DREAM MuvB core complex component, TUDOR gene similar, rb related pathway actor |
| Synonyms | 2700022J23Rik, BARA, BARPsv, lin-9 DREAM MuvB core complex component, LOC360888, LOC690072, mLin-9, TGS, TGS1, TGS2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LIN9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LIN9 C-terminal
- protein binding
- DIRP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypoplasia
- weight gain
- insulin-dependent diabetes mellitus
role in cell
- proliferation
- expression in
- growth
- cell cycle progression
- morphology
- transcription in
- transformation
- G2/M phase transition
- senescence
- checkpoint recovery in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LIN9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription, DNA-dependent
- DNA biosynthetic process
- reproductive process
- regulation of cell cycle
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcriptional repressor complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding