CXCL17 Gene Summary [Human]
The protein encoded by this gene is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs. The encoded protein also promotes tumorigenesis through an angiogenic activity. Finally, this protein exhibits strong antimicrobial activity against E. coli, S. aureus, Salmonella, P. aeruginosa, and C. albicans. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | CXCL17 |
| Official Name | C-X-C motif chemokine ligand 17 [Source:HGNC Symbol;Acc:HGNC:19232] |
| Ensembl ID | ENSG00000189377 |
| Bio databases IDs | |
| Aliases | C-X-C motif chemokine ligand 17 |
| Synonyms | C-X-C motif chemokine ligand 17, Dcip1, DMC, RGD1304717, UNQ473, VCC-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CXCL17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- protein binding
- cytokine
- VEGF co-regulated chemokine 1
Pathways
Biological processes and signaling networks where the CXCL17 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- osteoporosis
- idiopathic pulmonary fibrosis
- COVID-19
- colon adenocarcinoma
- colon epithelial cancer
- pancreatic epithelial cancer
- pancreatic ductal adenocarcinoma
- ductal pancreatic cancer
role in cell
- migration
- survival
- quantity
- number
- chemotaxis
- disruption
- invasion by
- infiltration by
- elevation in
- disruption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CXCL17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of monocyte chemotaxis
- angiogenesis
- macrophage chemotaxis
- negative regulation of inflammatory response
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of macrophage chemotaxis
- cell differentiation
- positive regulation vascular endothelial growth factor production
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- protein binding