MYCBP Gene Summary [Human]
The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]
Details
| Type | Protein Coding |
| Official Symbol | MYCBP |
| Official Name | MYC binding protein [Source:HGNC Symbol;Acc:HGNC:7554] |
| Ensembl ID | ENSG00000214114 |
| Bio databases IDs | |
| Aliases | MYC binding protein, associate of myc-1 |
| Synonyms | 5730488M09Rik, AMY-1, AW742590, MYC binding protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MYCBP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- ZIP_TSC22D-like
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- cytostasis
- growth
- proliferation
- colony formation
- downregulation in
- suppression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Golgi Apparatus
- Mitochondria
- nucleoplasm
- perinuclear space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MYCBP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- spermatogenesis
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity