Wnt10b Gene Summary [Mouse]
Predicted to enable cytokine activity and frizzled binding activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of cell differentiation; and regulation of DNA-templated transcription. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including genitourinary system; integumental system; jaw; nervous system; and surface ectoderm. Human ortholog(s) of this gene implicated in obesity; split hand-foot malformation 6; and tooth agenesis. Orthologous to human WNT10B (Wnt family member 10B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wnt10b |
| Official Name | wingless-type MMTV integration site family, member 10B [Source:MGI Symbol;Acc:MGI:108061] |
| Ensembl ID | ENSMUSG00000022996 |
| Bio databases IDs | |
| Aliases | wingless-type MMTV integration site family, member 10B |
| Synonyms | SHFM6, STHAG8, wingless-type MMTV integration site family, member 10B, WNT-12, Wnt family member 10B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wnt10b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt
- wnt family
- protein binding
- receptor binding
- found in Wnt-1
Pathways
Biological processes and signaling networks where the Wnt10b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- osteoarthritis
- lung adenocarcinoma formation
- obesity
- split-hand/foot malformation type 6
- tumorigenesis
- androgenic alopecia
- Parkinson disease
- diabetic nephropathy
- squamous cell lung cancer
role in cell
- expression in
- growth
- apoptosis
- quantity
- proliferation
- migration
- development
- differentiation
- cell cycle progression
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wnt10b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fungiform papilla development
- chondrocyte differentiation
- transcription from RNA polymerase II promoter
- fat cell differentiation
- positive regulation of osteoblast differentiation
- bone trabecula formation
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of anagen
- G2/M transition of mitotic cell cycle
- skeletal muscle fiber development
- cellular response to parathyroid hormone stimulus
- regulation of skeletal muscle tissue development
- osteoblast differentiation
- canonical Wnt receptor signaling pathway
- myoblast cell differentiation involved in skeletal muscle regeneration
- positive regulation of bone mineralization
- positive regulation of G2/M transition of mitotic cell cycle
- sensory perception of taste
- neuron differentiation
- negative regulation of fat cell differentiation
- positive regulation of canonical Wnt receptor signaling pathway
- smoothened signaling pathway
- myoblast development
- positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
- T cell differentiation
- epithelial cell differentiation
- cellular response to retinoic acid
- positive regulation of epithelial cell differentiation
- positive regulation of T cell differentiation
- negative regulation of epithelial cell proliferation
- lipid metabolic process
- cellular response to cAMP
- positive regulation of apoptotic process
- cell fate commitment
- hemopoietic stem cell proliferation
- protein stabilization
- regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- protein binding
- receptor agonist activity
- cytokine activity