Jade2 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Acts upstream of or within neuron projection extension; positive regulation of neurogenesis; and protein ubiquitination. Predicted to be located in nucleoplasm. Predicted to be part of histone acetyltransferase complex. Is expressed in central nervous system and genitourinary system. Orthologous to human JADE2 (jade family PHD finger 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Jade2 |
| Official Name | jade family PHD finger 2 [Source:MGI Symbol;Acc:MGI:1924151] |
| Ensembl ID | ENSMUSG00000020387 |
| Bio databases IDs | |
| Aliases | jade family PHD finger 2 |
| Synonyms | 1200017K05Rik, AI480685, jade family PHD finger 2, KIAA0239, mKIAA0239, PHF15 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Jade2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- histone acetyltransferase
- Enhancer of polycomb-like
- PHD-like zinc-binding domain
- ubiquitin protein ligase activity
- PHD finger superfamily
- enzyme
- protein binding
- PHD-zinc-finger like domain
- PHD-finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- non-insulin-dependent diabetes mellitus
- bipolar disorder
- nicotine dependence
- multiple sclerosis
- endometriosis
- stuttering
- lung cancer
role in cell
- expression in
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Jade2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- regulation of cell growth
- regulation of DNA biosynthetic process
- regulation of transcription, DNA-dependent
- regulation of DNA replication
- regulation of cell cycle
- regulation of transcription from RNA polymerase II promoter
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- histone acetyltransferase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- histone acetyltransferase activity (H4-K16 specific)
- histone acetyltransferase activity (H4-K8 specific)
- histone acetyltransferase activity (H4-K5 specific)
- histone acetyltransferase activity (H4-K12 specific)