Pak5 Gene Summary [Mouse]
Enables protein serine/threonine kinase activity. Acts upstream of or within learning or memory; locomotory behavior; and negative regulation of extrinsic apoptotic signaling pathway. Located in mitochondrion. Is active in synapse. Is expressed in brain and sciatic nerve. Orthologous to human PAK5 (p21 (RAC1) activated kinase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pak5 |
| Official Name | p21 (RAC1) activated kinase 5 [Source:MGI Symbol;Acc:MGI:1920334] |
| Ensembl ID | ENSMUSG00000039913 |
| Bio databases IDs | |
| Aliases | p21 (RAC1) activated kinase 5 |
| Synonyms | 2900083L08RIK, p21 (RAC1) activated kinase 5, PAK-7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pak5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTPase binding domain
- protein serine/threonine kinase
- p21 binding domain
- Protein kinase (unclassified specificity)
- autoinhibitory protein domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- activation loop
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- CRIB
- alcohol group acceptor phosphotransferase
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Pak5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Agrin Interactions at Neuromuscular Junction
- Angiopoietin Signaling
- CCR3 Signaling in Eosinophils
- CXCR4 Signaling
- Ephrin Receptor Signaling
- Epithelial Adherens Junction Signaling
- ErbB Signaling
- G-Protein Coupled Receptor Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- GNRH Signaling
- Integrin Signaling
- Natural Killer Cell Signaling
- PAK Signaling
- Paxillin Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Renal Cell Carcinoma Signaling
- Renin-Angiotensin Signaling
- Semaphorin Signaling in Neurons
- Serotonin Receptor Signaling
- TEC Kinase Signaling
- TNFR1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- psoriasis
- schizophrenia
- breast cancer
- major depression
- atopy
role in cell
- phosphorylation in
- apoptosis
- proliferation
- growth
- binding in
- development
- abnormal morphology
- stabilization
- induction
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Plasma Membrane
- Mitochondria
- cytosol
- trans Golgi network
- nucleoplasm
- nuclear envelope
- neurites
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pak5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- regulation of MAPK cascade
- cytoskeleton organization
- signal transduction
- protein phosphorylation
- learning
- memory
- locomotory behavior
- regulation of cell growth
- apoptotic process
- negative regulation of extrinsic apoptotic signaling pathway
- cell migration
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- cytoplasm
- mitochondrion
- cytosol
- synapse
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine kinase activity