Spdef Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Acts upstream of or within several processes, including epithelial cell differentiation; positive regulation of cell fate commitment; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human SPDEF (SAM pointed domain containing ETS transcription factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spdef |
| Official Name | SAM pointed domain containing ets transcription factor [Source:MGI Symbol;Acc:MGI:1353422] |
| Ensembl ID | ENSMUSG00000024215 |
| Bio databases IDs | |
| Aliases | SAM pointed domain containing ets transcription factor |
| Synonyms | bA375E1.3, LOC687360, PDEF, Pse, SAM pointed domain containing ETS transcription factor, Spdef1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spdef often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Sterile alpha motif (SAM)/Pointed domain
- transcription regulator
- double-stranded DNA binding
- SAM (Sterile alpha motif )
- Ets-domain
- protein binding
- sequence-specific DNA binding
Pathways
Biological processes and signaling networks where the Spdef gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- tumorigenesis
- prostatic carcinoma
- prostate cancer
- breast cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- insomnia
- HER2 negative hormone receptor negative breast cancer
role in cell
- expression in
- transactivation in
- production in
- apoptosis
- activation
- morphology
- migration
- cellular infiltration by
- growth
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell surface
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spdef gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lung goblet cell differentiation
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- intestinal epithelial cell development
- glandular epithelial cell development
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of apoptotic process
- cell differentiation
- epithelial cell fate commitment
- positive regulation of cell fate commitment
- negative regulation of cell fate commitment
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity