Plcd4 Gene Summary [Mouse]
Predicted to enable G-protein alpha-subunit binding activity; guanyl-nucleotide exchange factor activity; and phosphatidylinositol-4,5-bisphosphate phospholipase C activity. Acts upstream of or within acrosome reaction. Predicted to be located in cytosol and endoplasmic reticulum. Predicted to be active in plasma membrane. Is expressed in male reproductive gland or organ and nervous system. Orthologous to human PLCD4 (phospholipase C delta 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Plcd4 |
| Official Name | phospholipase C, delta 4 [Source:MGI Symbol;Acc:MGI:107469] |
| Ensembl ID | ENSMUSG00000026173 |
| Bio databases IDs | |
| Aliases | phospholipase C, delta 4 |
| Synonyms | 4921507K24RIK, phospholipase C delta 4, phospholipase C, delta 4, phospholipase C δ 4, phospholipase C, δ 4, PLC δ 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plcd4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phosphatidylinositol-specific phospholipase C, Y domain
- EF-hand domain pair
- EFh
- enzyme
- phospholipase C
- protein binding
- Pleckstrin homology-like domain
- phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
- EFh_PI-PLC
- phosphoinositide phospholipase C
- Phosphatidylinositol-specific phospholipase C, X domain
- Phospholipase C, catalytic domain (part: domain X)
- Phosphoinositide-specific phospholipase C, efhand-like
- EF hand
- guanyl-nucleotide exchange factor
- Phospholipase C, catalytic domain (part: domain Y)
- PH domain
- Protein kinase C conserved region 2 (CalB)
- Pleckstrin homology domain
- C2 domain
Pathways
Biological processes and signaling networks where the Plcd4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Adrenomedullin signaling pathway
- Antioxidant Action of Vitamin C
- Apelin Cardiomyocyte Signaling Pathway
- Cellular Effects of Sildenafil (Viagra)
- Dendritic Cell Maturation
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endothelin-1 Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Gap Junction Signaling
- Glioblastoma Multiforme Signaling
- Leptin Signaling in Obesity
- Melatonin Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- P2Y Purinergic Receptor Signaling Pathway
- P2Y Purinergic Receptor Signaling Pathway
- PPARα/RXRα Activation
- Protein Kinase A Signaling
- Role of NFAT in Cardiac Hypertrophy
- Serotonin Receptor Signaling
- Sphingosine-1-phosphate Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
- UVA-Induced MAPK Signaling
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- polycystic kidney disease
role in cell
- proliferation
- expression in
- activation in
- function
- colony formation
- signal transduction in
- acrosome reaction
- hydrolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular space
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plcd4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acrosome reaction
- lipid catabolic process
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- cytosol
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- protein binding
- calcium ion binding
- guanyl-nucleotide exchange factor activity