Uck2 Gene Summary [Mouse]
Predicted to enable cytidine kinase activity; identical protein binding activity; and uridine kinase activity. Predicted to be involved in CTP salvage and UMP salvage. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; cranium; integumental system; nervous system; and sensory organ. Orthologous to human UCK2 (uridine-cytidine kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Uck2 |
| Official Name | uridine-cytidine kinase 2 [Source:MGI Symbol;Acc:MGI:1931744] |
| Ensembl ID | ENSMUSG00000026558 |
| Bio databases IDs | |
| Aliases | uridine-cytidine kinase 2 |
| Synonyms | AI481316, TSA903, Uck3, UK, UMK, UMPK, uridine-cytidine kinase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Uck2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- nucleoside kinase
- nucleoside-phosphate kinase
- uridine kinase
- NK
- alcohol group acceptor phosphotransferase
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- organismal death
- testicular carcinoma
- testicular cancer
- Huntington disease
- androgenic alopecia
- multiple sclerosis
- testicular germ cell tumor
- germ cell neoplasia
- lung adenocarcinoma
regulates
role in cell
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Uck2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- CTP salvage
- CMP biosynthetic process
- UMP salvage
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- uridine kinase activity
- cytidine kinase activity