Uhmk1 Gene Summary [Mouse]
Enables ribonucleoprotein complex binding activity. Involved in neuron projection development and positive regulation of translational initiation. Located in axon; dendrite cytoplasm; and neuronal ribonucleoprotein granule. Is expressed in several structures, including central nervous system; heart; liver; metanephros; and retina. Orthologous to human UHMK1 (U2AF homology motif kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Uhmk1 |
| Official Name | U2AF homology motif (UHM) kinase 1 [Source:MGI Symbol;Acc:MGI:1341908] |
| Ensembl ID | ENSMUSG00000026667 |
| Bio databases IDs | |
| Aliases | U2AF homology motif (UHM) kinase 1 |
| Synonyms | 4732477C12RIK, 4930500M09Rik, C820018A03Rik, KIS, KIST, P-CIP2, U2AF homology motif kinase 1, U2AF homology motif (UHM) kinase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Uhmk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- RNA recognition motif (RRM) superfamily
- protein serine/threonine kinase
- protein kinase
- Protein Kinases, catalytic domain
- RNA recognition motif
- ATP binding
- ribonucleoprotein binding
- enzyme binding
- protein binding
- Protein kinase domain
Pathways
Biological processes and signaling networks where the Uhmk1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- COVID-19
- colorectal carcinoma
- colorectal carcinomagenesis
- cervical carcinoma
- epithelial uterine cancer
- cervical cancer
- obesity
- cortical visual impairment and intellectual disability
role in cell
- expression in
- proliferation
- growth
- phosphorylation in
- cell cycle progression
- apoptosis
- migration
- activation in
- processing in
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- soluble fraction
- intracellular membrane-bounded organelle
- cytoplasmic ribonucleoprotein granule
- Cytoplasm
- microsome
- nucleoplasm
- nuclear speckles
- synaptosomes
- axons
- dendrites
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Uhmk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translational initiation
- neuron projection development
- protein autophosphorylation
- regulation of cell cycle
- peptidyl-serine phosphorylation
- regulation of protein export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- intracellular membrane-bounded organelle
- dendrite cytoplasm
- neuronal ribonucleoprotein granule
- axon
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- RNA binding
- ribonucleoprotein complex binding
- protein serine/threonine kinase activity
- transferase activity
- enzyme binding