Lcp1 Gene Summary [Mouse]
Enables actin filament binding activity. Acts upstream of or within actin filament bundle assembly. Located in several cellular components, including actin filament; phagocytic cup; and ruffle. Is expressed in several structures, including brain; cardiovascular system; female reproductive system; gut; and yolk sac. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human LCP1 (lymphocyte cytosolic protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lcp1 |
| Official Name | lymphocyte cytosolic protein 1 [Source:MGI Symbol;Acc:MGI:104808] |
| Ensembl ID | ENSMUSG00000021998 |
| Bio databases IDs | |
| Aliases | lymphocyte cytosolic protein 1 |
| Synonyms | CP64, D14Ertd310e, FLJ39956, HEL-S-37, LC64P, LOC100503136, LPL, L-PLASTIN, lymphocyte cytosolic protein 1, PLASTIN, PLS2, pp65 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lcp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-terminal regulatory domain
- EF-hand, calcium binding motif
- Calponin homology domain
- EF-hand domain pair
- enzyme binding
- EFh
- protein binding
- phosphorylation site
- actin filament binding
- EF-hand domain
- EF hand
- integrin binding
- calponin homology (CH) domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- insulin-dependent diabetes mellitus
- nonalcoholic fatty liver disease
- rheumatoid arthritis
- Alzheimer disease
- pigmented villonodular synovitis
- diabetic nephropathy
- neurobehavioral deficit
- lichen planus
- androgenic alopecia
role in cell
- accumulation in
- phosphorylation in
- migration
- invasiveness
- differentiation
- growth
- chemotaxis
- motility
- formation
- polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cell junction
- ruffle
- invadopodia
- perinuclear region
- focal adhesions
- podosomes
- actin cytoskeleton
- Nucleus
- Plasma Membrane
- actin filaments
- granules
- cytosol
- apical cytoplasm
- apical cell surfaces
- basolateral cell surfaces
- glial cell projections
- actin stress fibers
- filopodia
- plasma
- phagocytic cups
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lcp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- wound healing, spreading of cells
- extracellular matrix disassembly
- T cell activation involved in immune response
- cortical actin cytoskeleton organization
- actin crosslink formation
- protein kinase A signaling cascade
- actin filament network formation
- regulation of intracellular protein transport
- organ regeneration
- cell migration
- positive regulation of podosome assembly
- actin filament bundle assembly
Cellular Component
Where in the cell the gene product is active
- actin filament
- phagocytic cup
- plasma membrane
- podosome
- extracellular space
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- focal adhesion
- cytoplasm
- stress fiber
- ruffle
- actin filament bundle
- actin cytoskeleton
- ruffle membrane
- cell junction
- filopodium
- cytosol
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- actin binding
- calcium ion binding
- GTPase binding
- integrin binding