PIWIL1 Gene Summary [Human]
This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Details
| Type | Protein Coding |
| Official Symbol | PIWIL1 |
| Official Name | piwi like RNA-mediated gene silencing 1 [Source:HGNC Symbol;Acc:HGNC:9007] |
| Ensembl ID | ENSG00000125207 |
| Bio databases IDs | |
| Aliases | piwi like RNA-mediated gene silencing 1 |
| Synonyms | CT80.1, HIWI, LOC102724010, MIWI, PIWI, PIWI1, piwi-like RNA-mediated gene silencing 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PIWIL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Piwi-like
- protein kinase binding
- mRNA binding
- PAZ domain
- enzyme
- protein binding
- single-stranded RNA binding
- Piwi domain
- RNA binding
- binding protein
- GAGE protein
- Argonaute linker 1 domain
- endoribonuclease
- PAZ
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- epithelial ovarian cancer
- ovarian cancer
- metastasis
- gastric adenocarcinoma
- gastric epithelial cancer
- male infertility
role in cell
- proliferation
- expression in
- apoptosis
- migration
- binding in
- cell cycle progression
- development
- ubiquitination in
- translation in
- condensation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic ribonucleoprotein granule
- punctate structures
- Nucleus
- polysomes
- cytosol
- sister chromatids
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PIWIL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- meiotic cell cycle
- spermatid development
- spermatogenesis
- sperm chromatin condensation
- gene silencing by RNA
- piRNA metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatoid body
- cytoplasm
- P granule
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- piRNA binding
- metal ion binding
- single-stranded RNA binding
- mRNA binding
- endoribonuclease activity