Sema5a Gene Summary [Mouse]
Enables axon guidance receptor activity and semaphorin receptor binding activity. Involved in several processes, including blood vessel endothelial cell proliferation involved in sprouting angiogenesis; negative regulation of endothelial cell apoptotic process; and regulation of signal transduction. Acts upstream of or within axonogenesis; branching involved in blood vessel morphogenesis; and detection of light stimulus involved in visual perception. Located in membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human SEMA5A (semaphorin 5A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Sema5a |
| Official Name | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A [Source:MGI Symbol;Acc:MGI:107556] |
| Ensembl ID | ENSMUSG00000022231 |
| Bio databases IDs | |
| Aliases | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A |
| Synonyms | 5930434A13, 9130201M22RIK, sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A, SEMAF, semaphorin 5A, semF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sema5a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- extracellular domain
- Plexin repeat
- axon guidance receptor
- protein binding
- syndecan binding
- glycosaminoglycan binding
- semaphorin domain
- binding protein
- semaphorin receptor binding
- cytoplasmic domain
- Spondin-like TSP1 domain
- Sema domain
- transmembrane receptor
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Sema5a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- dementia
- Parkinson disease
- squamous-cell carcinoma
- squamous cell cancer
- proliferative diabetic retinopathy
- doxorubicin induced cardiotoxicity
- preeclampsia
- glioma formation
- ischemic stroke
role in cell
- expression in
- phosphorylation in
- proliferation
- activation in
- migration
- chemotaxis
- binding in
- growth
- dysfunction
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sema5a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative chemotaxis
- positive chemotaxis
- nervous system development
- axon guidance
- cell adhesion
- blood vessel endothelial cell proliferation involved in sprouting angiogenesis
- diencephalon development
- positive regulation of angiogenesis
- cell chemotaxis
- axonal fasciculation
- positive regulation of endothelial cell chemotaxis
- negative regulation of endothelial cell apoptotic process
- negative regulation of cell adhesion
- cell-cell signaling
- positive regulation of canonical Wnt receptor signaling pathway
- negative regulation of axon extension involved in axon guidance
- positive regulation of axon extension involved in axon guidance
- neural crest cell migration
- positive regulation of actin filament depolymerization
- axon extension
- positive regulation of endothelial cell proliferation
- positive regulation of protein kinase B signaling cascade
- semaphorin-plexin signaling pathway
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- chondroitin sulfate proteoglycan binding
- heparan sulfate proteoglycan binding
- syndecan binding
- chemorepellent activity
- semaphorin receptor binding