N4bp1 Gene Summary [Mouse]
Predicted to enable RNA nuclease activity; mRNA binding activity; and ubiquitin binding activity. Involved in cellular response to UV; negative regulation of macromolecule metabolic process; and regulation of innate immune response. Located in PML body; cytosol; and nucleolus. Orthologous to human N4BP1 (NEDD4 binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | N4bp1 |
| Official Name | NEDD4 binding protein 1 [Source:MGI Symbol;Acc:MGI:2136825] |
| Ensembl ID | ENSMUSG00000031652 |
| Bio databases IDs | |
| Aliases | NEDD4 binding protein 1 |
| Synonyms | AI481586, BC004022, FLJ31821, NEDD4 binding protein 1, RGD1305179 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse N4bp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- K homology (KH) RNA-binding domain, type I
- mRNA binding
- ribonuclease
- ubiquitin binding
- enzyme
- protein binding
- Zc3h12a-like Ribonuclease NYN domain
- PIN (PilT N terminus) domain: Superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anemia
- renal glucosuria
- organismal death
- psoriasis
- squamous-cell carcinoma
- squamous cell cancer
- epidermal hyperplasia
role in cell
- production in
- molecular cleavage in
- number
- expression in
- function
- recognition by
- activation in
- phosphorylation in
- binding in
- oligomerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoli
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse N4bp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- regulation of innate immune response
- cellular response to UV
- negative regulation of protein ubiquitination
- negative regulation of cytokine production
- negative regulation of viral genome replication
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding
- mRNA binding
- ribonuclease activity