Adgrg1 Gene Summary [Mouse]
Enables several functions, including collagen binding activity; extracellular matrix binding activity; and heparin binding activity. Involved in several processes, including negative regulation of neuron migration; positive regulation of Rho protein signal transduction; and seminiferous tubule development. Acts upstream of or within cerebral cortex regionalization; hematopoietic stem cell homeostasis; and positive regulation of neural precursor cell proliferation. Located in glial limiting end-foot. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in bilateral frontoparietal polymicrogyria and bilateral perisylvian polymicrogyria. Orthologous to human ADGRG1 (adhesion G protein-coupled receptor G1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Adgrg1 |
| Official Name | adhesion G protein-coupled receptor G1 [Source:MGI Symbol;Acc:MGI:1340051] |
| Ensembl ID | ENSMUSG00000031785 |
| Bio databases IDs | |
| Aliases | adhesion G protein-coupled receptor G1 |
| Synonyms | adhesion G protein-coupled receptor G1, BFPP, BPPR, CDCBM14B, CDCBM15A, Cyt28, GPR56, LOC102554158, LOC103690329, LOC682401, TM7LN4, TM7XN1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adgrg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- 7 transmembrane receptor (Secretin family)
- extracellular matrix binding
- PTX/LNS-Like (PLL) domain
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- GPCR-Autoproteolysis-INducing (GAIN) subdomain A
- C-terminal transmembrane domain
- STP box
- collagen binding
- GPCR proteolysis site, GPS, motif
- heparin binding
Pathways
Biological processes and signaling networks where the Adgrg1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bilateral frontoparietal polymicrogyria
- hepatocellular carcinoma
- organismal death
- bleeding
- papillary thyroid carcinoma
- papillary thyroid cancer
- liver cancer
- epithelial cancer
- epithelial neoplasia
- cancer
role in cell
- migration
- expression in
- proliferation
- growth
- phosphorylation in
- activation in
- adhesion
- hypertrophy
- shape change
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- cell surface
- cellular membrane
- astrocyte projections
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adgrg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein kinase C signaling cascade
- positive regulation of Rho protein signal transduction
- layer formation in cerebral cortex
- cerebral cortex radial glia guided migration
- G-protein coupled receptor signaling pathway
- neural precursor cell proliferation
- negative regulation of cell proliferation
- cell-cell signaling
- cell adhesion
- cell surface receptor signaling pathway
- brain development
- Rho protein signal transduction
- positive regulation of cell adhesion
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- cerebral cortex regionalization
- angiogenesis
- seminiferous tubule development
- positive regulation of neural precursor cell proliferation
- vascular endothelial growth factor production
- cell migration
- negative regulation of neuron migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- membrane raft
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- G-protein coupled receptor activity
- protein binding
- collagen binding
- heparin binding