Ccr3 Gene Summary [Mouse]
Enables C-C chemokine binding activity and C-C chemokine receptor activity. Involved in positive regulation of angiogenesis and positive regulation of endothelial cell proliferation. Acts upstream of or within chemotaxis. Predicted to be located in endosome; extracellular space; and plasma membrane. Predicted to be active in cytoplasm and external side of plasma membrane. Is expressed in embryo and yolk sac. Human ortholog(s) of this gene implicated in asthma; ovary epithelial cancer; and rhinitis. Orthologous to human CCR3 (C-C motif chemokine receptor 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccr3 |
| Official Name | chemokine (C-C motif) receptor 3 [Source:MGI Symbol;Acc:MGI:104616] |
| Ensembl ID | ENSMUSG00000035448 |
| Bio databases IDs | |
| Aliases | chemokine (C-C motif) receptor 3 |
| Synonyms | CC-CKR-3, C-C motif chemokine receptor 3, CD193, CHEMOKINE CC3 receptor, CKR 3, Cmkbr1l2, CMKBR3, Eoxtaxin1 Receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- C-C chemokine receptor
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- chemokine receptor
- C-C chemokine binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Ccr3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nonalcoholic steatohepatitis
- cancer
- obesity
- epithelial neoplasia
- abdominal cancer
- epithelial cancer
- liver cancer
- liver neoplasia
- digestive system cancer
- atopic dermatitis
role in cell
- function
- binding
- migration
- expression in
- cytotoxicity
- number
- proliferation
- quantity
- accumulation
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- Extracellular Space
- cellular membrane
- endosomes
- granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccr3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell adhesion
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- positive regulation of angiogenesis
- cell chemotaxis
- elevation of cytosolic calcium ion concentration
- chemotaxis
- cellular defense response
- inflammatory response
- immune response
- chemokine-mediated signaling pathway
- positive regulation of endothelial cell proliferation
- calcium-mediated signaling
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- C-C chemokine binding
- protein binding
- C-C chemokine receptor activity
- chemokine receptor activity