Nfkbid Gene Summary [Mouse]
Enables NF-kappaB binding activity. Involved in T cell receptor signaling pathway and positive regulation of T-helper 17 cell differentiation. Acts upstream of or within several processes, including negative regulation of NF-kappaB transcription factor activity; negative regulation of canonical NF-kappaB signal transduction; and positive regulation of thymocyte apoptotic process. Located in nucleus. Orthologous to human NFKBID (NFKB inhibitor delta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nfkbid |
| Official Name | nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta [Source:MGI Symbol;Acc:MGI:3041243] |
| Ensembl ID | ENSMUSG00000036931 |
| Bio databases IDs | |
| Aliases | nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta |
| Synonyms | Ay078069, IKAPPAB, I-kappa-B-delta, IkappaBNS, ikB-delta, IkBNS, ikB-δ, I-κ-B-δ, NFKB inhibitor delta, NFKB inhibitor δ, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta, nuclear factor of κ light polypeptide gene enhancer in B cells inhibitor, δ, RGD1308055, TA-NFKBH |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nfkbid often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- NF-kappaB binding
- Ankyrin repeats (3 copies)
- protein binding
- Ankyrin repeat
Pathways
Biological processes and signaling networks where the Nfkbid gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- Angiopoietin Signaling
- April Mediated Signaling
- B Cell Activating Factor Signaling
- CD27 Signaling in Lymphocytes
- Dendritic Cell Maturation
- Glucocorticoid Receptor Signaling
- HER-2 Signaling in Breast Cancer
- Hypoxia Signaling in the Cardiovascular System
- IL-17A Signaling in Airway Cells
- Induction of Apoptosis by HIV1
- LPS-stimulated MAPK Signaling
- Lymphotoxin β Receptor Signaling
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- Molecular Mechanisms of Cancer
- NF-κB Signaling
- PEDF Signaling
- Prostate Cancer Signaling
- Protein Kinase A Signaling
- RANK Signaling in Osteoclasts
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- Small Cell Lung Cancer Signaling
- TNFR1 Signaling
- TNFR2 Signaling
- TWEAK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colitis
- streptozotocin induced type1 diabetes
- endotoxin shock response
role in cell
- function
- expression in
- proliferation
- apoptosis
- number
- invasion
- activation
- accumulation in
- differentiation
- frequency
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nfkbid gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- regulation of gene expression
- positive regulation of T-helper 17 cell differentiation
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding