Ifne Gene Summary [Mouse]
Predicted to enable cytokine activity and type I interferon receptor binding activity. Involved in defense response to bacterium and defense response to virus. Predicted to be active in extracellular space. Is expressed in diencephalon floor plate and midbrain floor plate. Orthologous to human IFNE (interferon epsilon). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ifne |
| Official Name | interferon epsilon [Source:MGI Symbol;Acc:MGI:2667156] |
| Ensembl ID | ENSMUSG00000045364 |
| Bio databases IDs | |
| Aliases | interferon epsilon |
| Synonyms | If1ea, IFNE1, IFN epsilon, IFNT1, Ifn-tau-1, IFN ε, INFE1, interferon epsilon, interferon, epsilon, interferon ε, interferon, ε, PRO655, RGD1565065 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ifne often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IFab
- cytokine
Pathways
Biological processes and signaling networks where the Ifne gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- infection by bacteria
- infection by Herpesviridae
role in cell
- differentiation
- expression in
- proliferation
- production in
- phosphorylation in
- apoptosis
- induction in
- cell cycle progression
- morphology
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ifne gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B cell differentiation
- positive regulation of peptidyl-serine phosphorylation of STAT protein
- B cell proliferation
- adaptive immune response
- T cell activation involved in immune response
- defense response to bacterium
- type I interferon-mediated signaling pathway
- natural killer cell activation involved in immune response
- response to exogenous dsRNA
- cytokine-mediated signaling pathway
- humoral immune response
- defense response to virus
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- interferon-alpha/beta receptor binding
- cytokine activity